| Date: | 25–31 October 2021 |
| Edition: | 5th |
| Surface: | Hard |
| Location: | Tyler, Texas, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $80,000 |
| Champs: |  Misaki Doi |
| Champd: |  Giuliana Olmos / Marcela Zacarías |
| Main Name: | Tyler Pro Challenge |
| Before Name: | Bellatorum Resources Pro Classic |
The 2021 Christus Health Pro Challenge was a professional women's tennis tournament played on outdoor hard courts. It was the fifth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Tyler, Texas, United States between 25 and 31 October 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Madison Brengle | 78 | 1 | ||
| Claire Liu | 88 | 2 | ||
 Brazil | Beatriz Haddad Maia | 94 | 3 | |
| Japan | Misaki Doi | 106 | 4 | |
 United Kingdom | Harriet Dart | 134 | 5 | |
 China | Wang Xiyu | 140 | 6 | |
| Caty McNally | 141 | 7 | ||
 Poland | Katarzyna Kawa | 159 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Sophie Chang Ellie Douglas
Katarina Kozarov Ashlyn Krueger Elizabeth Mandlik Whitney Osuigwe Amy ZhuSee main article: 2021 Christus Health Pro Challenge – Singles.
Misaki Doi def. Harriet Dart, 7–6(7–5), 6–2See main article: 2021 Christus Health Pro Challenge – Doubles.
Giuliana Olmos / Marcela Zacarías def. Misaki Doi / Katarzyna Kawa, 7–5, 1–6, [10–5]
