The 2021 Chile Open (also known as the Chile Dove Men+Care Open for sponsorship reasons) was a men's tennis tournament played on outdoor clay courts. It was the 23rd edition of the Chile Open, and part of the ATP 250 of the 2021 ATP Tour. It took place in Santiago, Chile from 8 through 14 March 2021.[1]
See main article: 2021 Chile Open – Singles.
Facundo Bagnis, 6–4, 6–7(3–7), 7–5See main article: 2021 Chile Open – Doubles.
Simone Bolelli / Máximo González def. Federico Delbonis / 
Jaume Munar, 7–6(7–4), 6–4| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Cristian Garín | 22 | 1 | ||
 France | Benoît Paire | 29 | 2 | |
| Spain | Pablo Andújar | 57 | 3 | |
 Serbia | Laslo Đere | 60 | 4 | |
 United States | Frances Tiafoe | 62 | 5 | |
| Italy | Salvatore Caruso | 79 | 6 | |
| Argentina | Federico Coria | 85 | 7 | |
| Argentina | Federico Delbonis | 86 | 8 |
The following players received wildcards into the singles main draw:
The following player received special exemption into the singles main draw:
The following players received entry from the qualifying draw:
Fabio Fognini → replaced by Jaume Munar Miomir Kecmanović → replaced by 
Andrej Martin
Daniel Elahi Galán Juan Ignacio Londero → replaced by Facundo Bagnis Pedro Martínez → replaced by Daniel Altmaier
Thiago Monteiro → replaced by Jozef Kovalík Guido Pella → replaced by Pedro Sousa| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Raven Klaasen |  Japan | Ben McLachlan | 69 | 1 | ||
| United States | Austin Krajicek | Franko Škugor | 74 | 2 | ||
| Brazil | Marcelo Demoliner |  Mexico | Santiago González | 93 | 3 | |
| Italy | Simone Bolelli | Argentina | Máximo González | 117 | 4 |
The following pairs received wildcards into the doubles main draw:
Federico Delbonis / Juan Ignacio Londero → replaced by Federico Delbonis / Jaume Munar