| Champ: |  Květa PeschkeAndrea Petkovic |
| Runner: |  Caroline Dolehide CoCo Vandeweghe |
| Score: | 6–3, 6–1 |
| Type: | singles doubles |
| Edition: | 1st |
| After Name: | Chicago Fall Tennis Classic – Singles |
See main article: article and 2021 Chicago Fall Tennis Classic.
This was the first edition of the event.[1]
Květa Peschke and Andrea Petkovic won the title, defeating Caroline Dolehide and CoCo Vandeweghe in the final, 6–3, 6–1. This was Petkovic's first WTA doubles title.
Elise Mertens was in contention to regain the WTA no. 1 doubles ranking by winning the title, but she and partner Hsieh Su-wei withdrew from the competition in the quarterfinals. Barbora Krejčíková accordingly retained the top ranking.
The top four seeds received a bye into the second round.