See main article: article and 2021 Chicago Challenger.
Mona Barthel and Kristýna Plíšková were the defending champions,[1] but Plíšková chose not to participate.
Eri Hozumi and Peangtarn Plipuech won the title, defeating Barthel and Hsieh Yu-chieh in the final, 7–5, 6–2.