| Year: | 2021 |
| Team: | Charleston Southern Buccaneers |
| Sport: | football |
| Conference: | Big South Conference |
| Short Conf: | Big South |
| Record: | 4–6 |
| Conf Record: | 3–4 |
| Head Coach: | Autry Denson |
| Hc Year: | 3rd |
| Off Coach: | Klay Koester |
| Oc Year: | 2nd |
| Def Coach: | Zane Vance |
| Dc Year: | 5th |
| Stadium: | Buccaneer Field |
The 2021 Charleston Southern Buccaneers football team represented Charleston Southern University as a member of the Big South Conference during the 2021 NCAA Division I FCS football season. Led by third-year head coach Autry Denson, the Buccaneers compiled an overall record of 4–6 with a mark of 3–4 in conference play, placing in a fourth-way tie for third in the Big South. Charleston Southern played home games at Buccaneer Field in Charleston, South Carolina.
See also: 2021 East Carolina Pirates football team.
| ECU –24.5 | 59 |
| Statistics | Charleston Southern | East Carolina |
|---|---|---|
| First downs | 34 | 14 |
| Total yards | 536 | 388 |
| Rushing yards | 131 | 150 |
| Passing yards | 405 | 238 |
| Turnovers | 1 | 2 |
| Time of possession | 31:27 | 28:33 |
| Team | Category | Player | Statistics |
|---|---|---|---|
| Charleston Southern | Passing | Jack Chambers | 38/61, 405 yds, 2 TD, 1 INT |
| Rushing | JD Moore | 14 car, 58 yds, 1 TD | |
| Receiving | Garris Schwarting | 8 rec, 94 yds | |
| East Carolina | Passing | 17/26, 238 yds, 1 TD, 2 INT | |
| Rushing | 13 car, 125 yds, 1 TD | ||
| Receiving | 3 rec, 95 yds, 1 TD |
See also: 2021 Georgia Bulldogs football team.