The 2021 Challenger La Manche was a professional tennis tournament played on indoor hard courts. It was the 28th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Cherbourg, France between 8 and 14 February 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Denis Kudla | 116 | 1 | ||
 France | Antoine Hoang | 119 | 2 | |
| France | Arthur Rinderknech | 135 | 3 | |
 Austria | Jurij Rodionov | 148 | 4 | |
| Peter Gojowczyk | 151 | 5 | ||
 Spain | Bernabé Zapata Miralles | 153 | 6 | |
| Austria | Sebastian Ofner | 162 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Challenger La Manche – Singles.
Ruben Bemelmans def. 
Lukáš Rosol 6–4, 6–4.See main article: 2021 Challenger La Manche – Doubles.
Lukáš Klein / Alex Molčan def. Antoine Hoang / Albano Olivetti 1–6, 7–5, [10–6].