See main article: 2021 Cassis Open Provence.
André Göransson and Sem Verbeek were the defending champions[1] but chose not to defend their title.
Sriram Balaji and Ramkumar Ramanathan won the title after defeating Hans Hach Verdugo and Miguel Ángel Reyes-Varela 6–4, 3–6, [10–6] in the final.