See main article: 2021 Cary Challenger.
Teymuraz Gabashvili and Dennis Novikov were the defending champions[1] but only Novikov chose to defend his title, partnering Christian Harrison. Novikov successfully defended his title.
Harrison and Novikov won the title after defeating Petros Chrysochos and Michail Pervolarakis 6–3, 6–3 in the final.