| Tourney Name: | Caribbean Series |
| Year: | 2021 |
| City: | Mazatlán |
| Country: | Mexico |
| Dates: | January 31, 2021 - February 6, 2021 |
| Num Teams: | 6 |
| Champion Other: |  Águilas Cibaeñas |
| Num Championships: | 6 |
| Second Other: |  Criollos de Caguas |
| Venues: | 1 |
| Cities: | 1 |
| Prevseason: | 2020 |
| Nextseason: | 2022 |
The 2021 Caribbean Series (Serie del Caribe) was the 63rd edition of the international competition featuring the champions of the Colombian Professional Baseball League, Dominican Professional Baseball League, Mexican Pacific League, Panamanian Professional Baseball League, Puerto Rican Professional Baseball League, and Venezuelan Professional Baseball League. It took place from January 31 to February 6, 2021, at Estadio Teodoro Mariscal in Mazatlán, Mexico.
Spectators were allowed to attend games, though the stadium only operated at 45% of capacity due to COVID-19 restrictions. Face coverings and socially distanced seating guidelines were enforced.[1]
The Preliminary Round consisted of a fifteen-game round robin, after which the top 4 teams advanced to the Semifinal Round (1st vs. 4th, 2nd vs. 3rd). The winners of the semifinal games then squared off in the Final.
| Team | Manager | Means of qualification | |
|---|---|---|---|
 Caimanes de Barranquilla | José Mosquera | Winners of the 2020–21 Colombian Professional Baseball League | |
 Tomateros de Culiacán | Benji Gil | Winners of the 2020–21 Mexican Pacific League | |
 Federales de Chiriquí |  Alfonso Urquiola | Runners-up of the 2019–20 Panamanian Professional Baseball League | |
| Criollos de Caguas | Ramón Vázquez | Winners of the 2020–21 Puerto Rican Professional Baseball League | |
| Águilas Cibaeñas | Félix Fermín | Winners of the 2020–21 Dominican Professional Baseball League | |
 Caribes de Anzoátegui |  Mike Alvarez | Winners of the 2020–21 Venezuelan Professional Baseball League |
Time zone: Mountain Standard Time (UTC–7)
| Date | Time | Away | Result | Home | Stadium | |
|---|---|---|---|---|---|---|
| February 5 | 15:00 | Federales de Chiriquí | 3–4 | Águilas Cibaeñas | Estadio Teodoro Mariscal | |
| February 5 | 20:00 | Tomateros de Culiacán | 1–2 | Criollos de Caguas | Estadio Teodoro Mariscal |
| Position | width=160 | Player |
|---|---|---|
| Starting Pitcher | Carlos Martínez | |
| Relief Pitcher | Jumbo Díaz | |
| Catcher | Yadier Molina | |
| First Baseman | Ronald Guzmán | |
| Second Baseman | Robinson Canó | |
| Third Baseman | Jordan Díaz | |
| Shortstop | Jonathan Araúz | |
| Outfielders | Melky Cabrera Juan Lagares Jarren Duran | |
| Designated Hitter | Jesse Castillo | |
| Manager | Félix Fermín |