The 2021 Cannons Lacrosse Club season was the Cannons Lacrosse Club's 21st season and their first Premier Lacrosse League season.
| Date | Opponent | Result | |
|---|---|---|---|
| June 4 | L 12-13 | ||
| June 6 | Waterdogs | W 13-7 | |
| June 12 | Whipsnakes | L 15-14 | |
| June 27 | Atlas | L 17-18 | |
| July 3 | Chaos | L 10-14 | |
| July 9 | Waterdogs | L 19-7 | |
| July 11 | Archers | W 13-12 | |
| August 1 | Atlas | L 12-13 | |
| August 14 | Chrome | W 13-10 | |
| August 20 | Archers | L10-13 |
It was announced that the Cannons would join the PLL as part of the MLL–PLL merger on December 16, 2020. They held their expansion draft on March 13, 2021.[1]
The Cannons moved from Veterans Memorial Stadium (Quincy, Massachusetts) to Medford when hosting their preseason training. They also rebranded from the "Boston Cannons" to Cannons Lacrosse Club.[2]
The Cannons played their first PLL game in Gillette Stadium on June 4, 2021 in a 12-13 loss to Redwoods Lacrosse Club. They finished the season 3-6, earning a playoff spot.[3]
The Cannons were eliminated from the playoffs in a quarterfinals 13-9 loss to Atlas Lacrosse Club.