| Date: | 15–21 November |
| Edition: | 10th |
| Surface: | Clay |
| Location: | Campinas, Brazil |
| Champs: |  Sebastián Báez |
| Champd: |  Rafael Matos / Felipe Meligeni Alves |
The 2021 Campeonato Internacional de Tênis de Campinas was a professional tennis tournament played on clay courts. It was the tenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Campinas, Brazil between 15 and 21 November 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Federico Coria | 70 | 1 | |
 Spain | Jaume Munar | 89 | 2 | |
| Argentina | Juan Manuel Cerúndolo | 91 | 3 | |
| Brazil | Thiago Monteiro | 95 | 4 | |
| Pablo Cuevas | 97 | 5 | ||
 Colombia | Daniel Elahi Galán | 102 | 6 | |
| Argentina | Sebastián Báez | 111 | 7 | |
| Argentina | Francisco Cerúndolo | 112 | 8 |
The following players received wildcards into the singles main draw:
Matheus Bueres Gustavo Heide Gilbert Klier JúniorThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2021 Campeonato Internacional de Tênis de Campinas – Singles.
Sebastián Báez def. Thiago Monteiro 6–1, 6–4.See main article: 2021 Campeonato Internacional de Tênis de Campinas – Doubles.
Rafael Matos / Felipe Meligeni Alves def. Gilbert Klier Júnior / Matheus Pucinelli de Almeida 6–3, 6–1.