| Champ: |  Juan Manuel Cerúndolo |
| Runner: |  Albert Ramos Viñolas |
| Score: | 6–0, 2–6, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Córdoba Open |
| After Name: | Córdoba Open |
See main article: 2021 Córdoba Open.
Cristian Garín was the defending champion, but chose not to defend his title.
Juan Manuel Cerúndolo won the title, defeating Albert Ramos Viñolas in the final 6–0, 2–6, 6–2. Cerúndolo, who started the week ranked 335th and went through qualifying, became the first player to win a tournament on his ATP Tour debut since Santiago Ventura in 2004.
The top four seeds received a bye into the second round.