| Champ: |  Rafael Matos Felipe Meligeni Alves |
| Runner: | Romain Arneodo Benoît Paire |
| Score: | 6–4, 6–1 |
| Type: | singles doubles |
See main article: 2021 Córdoba Open.
Marcelo Demoliner and Matwé Middelkoop were the defending champions, but Middelkoop decide to participate in the 2021 Open Sud de France instead. Demoliner was pairing up with Santiago González, but they lost in the first round to Guillermo Durán and Andrés Molteni.
Rafael Matos and Felipe Meligeni Alves won the title, defeating Romain Arneodo and Benoît Paire in the final, 6–4, 6–1.