| Date: | 20–28 February |
| Category: | ATP Tour 250 series |
| Prize Money: | $393,935 |
| Draw: | 28S / 16D |
| Surface: | Clay / outdoor |
| Location: | Córdoba, Argentina |
| Venue: | Estadio Mario Alberto Kempes |
| Edition: | 3rd |
| Champs: |  Juan Manuel Cerúndolo[1] |
| Champd: |  Rafael Matos / Felipe Meligeni Alves[2] |
The 2021 Córdoba Open was a men's tennis tournament played on outdoor clay courts. It was the third edition of the Córdoba Open, and part of the ATP Tour 250 series of the 2021 ATP Tour. It took place at the Estadio Mario Alberto Kempes in Córdoba, Argentina, from 20 February until 28 February 2021.[3]
See main article: 2021 Córdoba Open – Singles.
Juan Manuel Cerúndolo defeated 
Albert Ramos Viñolas, 6–0, 2–6, 6–2.See main article: 2021 Córdoba Open – Doubles.
Rafael Matos / Felipe Meligeni Alves defeated Romain Arneodo / 
Benoît Paire, 6–4, 6–1.| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 3 | 0 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Singles | $24,110 | $17,810 | $13,350 | $9,125 | $6,235 | $4,450 | $3,360 | $2,280 | $1,260 | |||
| Doubles | $8,400 | $6,140 | $4,680 | $3,350 | $2,450 | |||||||
| Doubles prize money per team | ||||||||||||
| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Argentina | Diego Schwartzman | 9 | 1 | ||
| France | Benoît Paire | 29 | 2 | ||
 Serbia | Miomir Kecmanović | 41 | 3 | ||
| Argentina | |||||
| Spain | Albert Ramos Viñolas | 46 | 5 | ||
| Dominik Koepfer | 70 | 6 | |||
| Brazil | Thiago Monteiro | 74 | 7 | ||
| Argentina | Federico Delbonis | 80 | 8 | ||
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Pablo Andújar → replaced by Thiago Seyboth Wild
Salvatore Caruso → replaced by 
Andrej Martin Jozef Kovalík Laslo Đere → replaced by 
Hugo Dellien Pedro Martínez → replaced by 
Daniel Elahi Galán Guido Pella → replaced by João Menezes| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Austin Krajicek | Franko Škugor | 71 | 1 | |||
| Brazil | Marcelo Demoliner |  Mexico | Santiago González | 90 | 2 | |
| Ariel Behar |  Ecuador | Gonzalo Escobar | 119 | 3 | ||
 Bosnia and Herzegovina | Tomislav Brkić | Serbia | Nikola Ćaćić | 137 | 4 |
The following pairs received wildcards into the doubles main draw:
Marco Cecchinato / Guido Pella → replaced by Thiago Monteiro / Fernando Romboli Salvatore Caruso / Máximo González → replaced by Federico Delbonis / Juan Ignacio Londero Pablo Andújar / Pedro Martínez → replaced by Federico Coria / Hugo Dellien
Oliver Marach → replaced by Rafael Matos / Felipe Meligeni Alves