| Champ: |  Jasmine Paolini |
| Runner: | Arantxa Rus |
| Score: | 6–2, 7–6(7–4) |
| Type: | singles doubles |
| Before Name: | Bol Open – Singles |
| After Name: | Bol Open – Singles |
| Before Year: | 2019 |
See main article: article and 2021 Bol Open.
Tamara Zidanšek was the two-time defending champion, having won the last edition in 2019,[1] however she was unable to defend her title as she was still competing at the 2021 French Open, reaching the semi-final of the Grand Slam.
Jasmine Paolini won the title, defeating Arantxa Rus in the final, 6–2, 7–6(7–4).