| Date: | 26 April–2 May 2021 |
| Edition: | 19th |
| Surface: | Clay |
| Location: | Charlottesville, Virginia, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Claire Liu |
| Champd: |  Anna Danilina /  Arina Rodionova |
| Before Year: | 2019 |
The 2021 Boar's Head Resort Women's Open was a professional women's tennis tournament played on outdoor clay courts. It was the nineteenth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Charlottesville, Virginia, United States between 26 April and 2 May 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Madison Brengle | 80 | 1 | ||
 Egypt | Mayar Sherif | 123 | 2 | |
| Kristie Ahn | 124 | 3 | ||
 Romania | Irina Bara | 134 | 4 | |
 Belarus | Olga Govortsova | 142 | 5 | |
 China | Wang Xinyu | 145 | 6 | |
 United Kingdom | Harriet Dart | 150 | 7 | |
 Poland | Magdalena Fręch | 157 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Katie Boulter Hanna Chang
Ulrikke Eikeri Jamie Loeb Maria Mateas Grace MinSee main article: 2021 Boar's Head Resort Women's Open – Singles.
Claire Liu def. Wang Xinyu, 3–6, 6–4, 4–1, ret.See main article: 2021 Boar's Head Resort Women's Open – Doubles.
Anna Danilina / Arina Rodionova def. 
Erin Routliffe / Aldila Sutjiadi, 6–1, 6–3