See main article: 2020–21 Billie Jean King Cup Americas Zone. The play-offs of the 2021 Billie Jean King Cup Americas Zone Group II were the final stages of the Group II zonal competition involving teams from the Americas. Using the positions determined in their pools, the fifteen teams faced off to determine their placing in the 2021 Billie Jean King Cup Americas Zone Group II. The top two teams advanced to Billie Jean King Cup Americas Zone Group I.
| Placing | Pool A (Panama City) | Pool B (Panama City) | Pool A (La Paz) | Pool B (La Paz) |
|---|---|---|---|---|
| 1 | ||||
| 2 | ||||
| 3 | ||||
| 4 | ||||
The first placed teams of each pool were drawn in head-to-head round. The winners advanced to Group I in 2022.
The second placed teams of each pool were drawn in head-to-head rounds to find the 3rd placed teams.
The third placed teams of each pool were drawn in head-to-head rounds to find the 5th placed teams.
| Placing | Teams | ||
| Promoted/First | |||
| Second | |||
| Third | |||
| Fourth | |||
| Fifth | |||
| Sixth | |||
| Seventh | |||