| Date: | 22–28 November |
| Edition: | 1st |
| Surface: | Hard |
| Location: | Manama, Bahrain |
| Champs: |  Ramkumar Ramanathan |
| Champd: | Nuno Borges / Francisco Cabral |
| After Year: | 2023 |
The 2021 Bahrain Ministry of Interior Tennis Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Manama, Bahrain between 22 and 28 November 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Moldova, Republic of | ||||
 Turkey | Cem İlkel | 145 | 2 | |
| Turkey | Altuğ Çelikbilek | 161 | 3 | |
 Australia | Christopher O'Connell | 174 | 4 | |
| India | Prajnesh Gunneswaran | 197 | 5 | |
| India | Ramkumar Ramanathan | 222 | 6 | |
 United Kingdom | Jay Clarke | 229 | 7 | |
 Bosnia and Herzegovina | Mirza Bašić | 234 | 8 |
The following players received wildcards into the singles main draw:
Hasan Abdulnabi Yankı Erel
Iván Marrero CurbeloThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry into the singles main draw as a lucky loser:
See main article: 2021 Bahrain Ministry of Interior Tennis Challenger – Singles.
Ramkumar Ramanathan def. 
Evgeny Karlovskiy 6–1, 6–4.See main article: 2021 Bahrain Ministry of Interior Tennis Challenger – Doubles.
Maximilian Neuchrist / Michail Pervolarakis 7–5, 6–7(5–7), [10–8].
