| Date: | 13–19 September |
| Edition: | 25th |
| Category: | WTA 250 tournaments |
| Prize Money: | $235,238 |
| Surface: | Hard (indoor) |
| Location: | Kockelscheuer, Luxembourg |
| Champs: | Clara Tauson |
| Champd: |  Greet Minnen / Alison Van Uytvanck |
| Main Name: | Luxembourg Open |
| Before Year: | 2019 |
The 2021 BGL BNP Paribas Luxembourg Open was a professional women's tennis tournament played on indoor hard courts sponsored by BNP Paribas. It was the 25th edition of the Luxembourg Open, and part of the WTA 250 tournaments category of the 2021 WTA Tour. It was held in Kockelscheuer, Luxembourg from 13 to 19 September 2021.[1]
See main article: 2021 BGL Luxembourg Open – Singles.
See main article: 2021 BGL Luxembourg Open – Doubles.
Greet Minnen / Alison Van Uytvanck def. 
Erin Routliffe / Kimberley Zimmermann 6–3, 6–3| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 280 | 180 | 110 | 60 | 30 | 1 | 18 | 12 | 1 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 1 |
| Event | W | F | SF | QF | Round of 16 | Round of 321 | width=85 | Q2 | width=85 | Q1 |
| Singles | €23,548 | €13,224 | €8,145 | €4,676 | €2,990 | €2,450 | €1,575 | €1,024 | ||
| Doubles * | €8,306 | €4,838 | €3,064 | €1,854 | €1,412 |
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Belinda Bencic[2] | 12 | 1 | ||
| Belgium | Elise Mertens | 16 | 2 | |
| Jeļena Ostapenko | 30 | 3 | ||
 Russian Federation | Ekaterina Alexandrova | 34 | 4 | |
 Czech Republic | Markéta Vondroušová | 38 | 5 | |
 China | Zhang Shuai | 49 | 6 | |
| Russian Federation | Liudmila Samsonova | 52 | 7 | |
 France | Alizé Cornet | 56 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Clara Burel → replaced by Océane Dodin
Astra Sharma Kateřina Siniaková → replaced by 
Aliaksandra Sasnovich
Nina Stojanović → replaced by Clara Tauson| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Czech Republic | Marie Bouzková | Czech Republic | Lucie Hradecká | 93 | 1 | |
 India | Sania Mirza | China | Zhang Shuai | 150 | 2 | |
 Japan | Eri Hozumi | Japan | Makoto Ninomiya | 162 | 3 | |
| Belarus | Lidziya Marozava |  Romania | Andreea Mitu | 178 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry using a protected ranking:
Kaitlyn Christian → replaced by Kaitlyn Christian / 
Anna Karolína Schmiedlová
