| Champ: |  Tomislav Brkić Nikola Ćaćić |
| Runner: | Ariel Behar Gonzalo Escobar |
| Score: | 6–3, 7–5 |
| Type: | singles doubles |
See main article: 2021 Argentina Open.
Marcel Granollers and Horacio Zeballos were the defending champions, but they decided not to participate this year.
Tomislav Brkić and Nikola Ćaćić won the title, defeating Ariel Behar and Gonzalo Escobar in the final, 6–3, 7–5.