| Champ: |  Alex de Minaur |
| Runner: |  Alexander Bublik |
| Score: | 2–0 ret. |
| Edition: | 4th |
| Draw: | 32 (6 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Year: | 2019 |
See main article: 2021 Antalya Open.
Lorenzo Sonego was the defending champion,[1] but chose not to participate. Alex de Minaur defeated Alexander Bublik in the final, 2–0, after Bublik retired with an ankle injury.