| Date: | 6–12 December |
| Edition: | 4th |
| Surface: | Clay |
| Location: | Antalya, Turkey |
| Champs: |  Evgenii Tiurnev |
| Champd: | Hsu Yu-hsiou /  Oleksii Krutykh |
| Main Name: | Antalya Challenger |
| Before Year: | 2021 |
| Before Name: | Antalya Challenger III |
| After Name: | Antalya Challenger |
| After Year: | 2023 |
The 2021 Antalya Challenger IV was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Antalya, Turkey between 6 and 12 December 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Turkey | Cem İlkel | 144 | 1 | |
 India | ||||
| Duje Ajduković | 251 | 3 | ||
 United Kingdom | Ryan Peniston | 284 | 4 | |
 Italy | Riccardo Bonadio | 298 | 5 | |
 Spain | Javier Barranco Cosano | 305 | 6 | |
 Bosnia and Herzegovina | Nerman Fatić | 307 | 7 | |
 Serbia | ||||
| Russian Federation | Evgenii Tiurnev | 319 | 9 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Andrey Chepelev
Cezar Crețu Marsel İlhanThe following players received entry as lucky losers:
See main article: 2021 Antalya Challenger IV – Singles.
Evgenii Tiurnev def. Oleg Prihodko 3–6, 6–4, 6–4.See main article: 2021 Antalya Challenger IV – Doubles.
Oleksii Krutykh def. 
Sanjar Fayziev / Markos Kalovelonis 6–1, 7–6(7–5).