| Date: | 1–7 February |
| Edition: | 2nd |
| Surface: | Clay |
| Location: | Antalya, Turkey |
| Champs: |  Carlos Taberner |
| Champd: |  Denys Molchanov /  Aleksandr Nedovyesov |
| Main Name: | Antalya Challenger |
| Before Year: | 2021 |
| Before Name: | Antalya Challenger |
| After Name: | Antalya Challenger III |
| After Year: | 2021 |
The 2021 Antalya Challenger II was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Antalya, Turkey between 1 and 7 February 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| João Sousa | 92 | 1 | ||
| Spain | Jaume Munar | 110 | 2 | |
 Colombia | Daniel Elahi Galán | 115 | 3 | |
 Brazil | Thiago Seyboth Wild | 118 | 4 | |
 Slovakia | Jozef Kovalík | 125 | 5 | |
 Argentina | Facundo Bagnis | 126 | 6 | |
 Italy | Lorenzo Musetti | 129 | 7 | |
| Daniel Altmaier | 132 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Antalya Challenger II – Singles.
Carlos Taberner def. Jaume Munar 6–4, 6–1.See main article: 2021 Antalya Challenger II – Doubles.
Denys Molchanov / Aleksandr Nedovyesov def. 
Robert Galloway / Alex Lawson 6–4, 7–6(7–2).
