| Date: | 25–31 January |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Antalya, Turkey |
| Champs: |  Jaume Munar |
| Champd: |  Denys Molchanov /  Aleksandr Nedovyesov |
| After Name: | Antalya Challenger II |
| After Year: | 2021 |
The 2021 Antalya Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Antalya, Turkey between 25 and 31 January 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Jaume Munar | 110 | 1 | |
 Colombia | Daniel Elahi Galán | 115 | 2 | |
 Brazil | Thiago Seyboth Wild | 118 | 3 | |
 Argentina | Facundo Bagnis | 125 | 4 | |
 Italy | Lorenzo Musetti | 129 | 5 | |
| Daniel Altmaier | 130 | 6 | ||
 Slovakia | Jozef Kovalík | 131 | 7 | |
| Argentina | Leonardo Mayer | 135 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Antalya Challenger – Singles.
Jaume Munar def. Lorenzo Musetti 6–7(7–9), 6–2, 6–2.See main article: 2021 Antalya Challenger – Doubles.
Denys Molchanov / Aleksandr Nedovyesov def. 
Luis David Martínez / David Vega Hernández 3–6, 6–4, [18–16].
