The 2021 Andalucía Open (also known as the 2021 AnyTech365 Andalucía Open for sponsorship reasons) was a tournament on the 2021 ATP Tour. It was played on outdoor clay courts in Marbella, Spain. It was organised with a single-year licence in 2021, and was held at Club de Tennis Puente Romano from April 5 to 11, 2021.[1] This was the 4th edition of the Challenger 80 tournament held in Puente Romano in Marbella. It was also the first edition of ATP 250. So this year professional tennis was played for the first time for two weeks. AnyTech365 Andalucía Open becomes the fourth ATP Tour tournament in Spain, alongside competitions in Madrid, Barcelona and Mallorca.[2]
See main article: 2021 Andalucía Open – Singles.
Pablo Carreño Busta def. Jaume Munar, 6–1, 2–6, 6–4See main article: 2021 Andalucía Open – Doubles.
Gonzalo Escobar def. 
Tomislav Brkić / 
Nikola Ćaćić, 6–2, 6–4| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | €40,100 | €28,750 | €20,465 | €13,650 | €8,770 | €5,275 | €2,580 | €1,340 | ||
| Doubles* | €14,970 | €10,730 | €7,060 | €4,590 | €2,690 |
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Pablo Carreño Busta | 15 | 1 | |
 Italy | Fabio Fognini | 17 | 2 | |
 Norway | Casper Ruud | 25 | 3 | |
| Spain | Albert Ramos Viñolas | 47 | 4 | |
| Spain | Alejandro Davidovich Fokina | 55 | 5 | |
| Spain | Feliciano López | 64 | 6 | |
 Korea, Republic of | Kwon Soon-woo | 79 | 7 | |
 Argentina | Federico Delbonis | 80 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Pablo Andújar → replaced by 
Mikhail Kukushkin Roberto Bautista Agut → replaced by Facundo Bagnis
Richard Gasquet → replaced by Francisco Cerúndolo
Norbert Gombos Dušan Lajović → replaced by 
Taro Daniel
Cameron Norrie → replaced by Roberto Carballés Baena
Alexei Popyrin → replaced by 
Ilya Ivashka
Andrey Rublev → replaced by Damir Džumhur Pedro Martínez| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Belgium | Sander Gillé | Belgium | Joran Vliegen | 74 | 1 | |
 New Zealand | Marcus Daniell |  Austria | Philipp Oswald | 78 | 2 | |
| Marcelo Arévalo | Matwé Middelkoop | 97 | 3 | |||
| Australia | Luke Saville | Australia | John-Patrick Smith | 107 | 4 |
The following pairs received wildcards into the doubles main draw:
Marcelo Demoliner / 
Santiago González → replaced by Santiago González / Miguel Ángel Reyes-Varela Cameron Norrie / Matt Reid → replaced by 
Ričardas Berankis / Artem Sitak