| Champ: |  Pablo Carreño Busta |
| Runner: | Jaume Munar |
| Score: | 6–1, 2–6, 6–4 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| Edition: | 1st |
| After Name: | Andalucía Open – Singles |
| Main Name: | Andalucia Tennis Experience Andalucía Open |
See main article: article and 2021 Andalucía Open.
Pablo Carreño Busta defeated Jaume Munar in the final, 6–1, 2–6, 6–4 to win the inaugural Men's Singles tennis title at the 2021 Andalucía Open. Notably, this was the first tournament in ATP history to feature 4 semifinalists from the same nation.
This was the first edition of the tournament, primarily organised due to the cancellation of some tournaments in 2021, due to the COVID-19 pandemic.[1]
The top four seeds received a bye into the second round.