| Date: | 5–11 July 2021 |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Amstelveen, Netherlands |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: | Quirine Lemoine |
| Champd: | Suzan Lamens / Quirine Lemoine |
The 2021 Amstelveen Women's Open was a professional women's tennis tournament played on outdoor clay courts. It was the first edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Amstelveen, Netherlands between 5 and 11 July 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 China | Wang Xiyu | 137 | 1 | |
 Austria | Barbara Haas | 156 | 2 | |
 Belgium | Maryna Zanevska | 192 | 3 | |
| Austria | Julia Grabher | 204 | 4 | |
| Tereza Mrdeža | 206 | 5 | ||
 Italy | Martina Di Giuseppe | 209 | 6 | |
 Georgia | Ekaterine Gorgodze | 210 | 7 | |
| Despina Papamichail | 227 | 8 |
The following players received wildcards into the singles main draw:
Nikki RedelijkThe following player received entry using a junior exempt:
The following players received entry as special exempts:
The following players received entry from the qualifying draw:
Cristiana Ferrando
Jaimee Fourlis Verena Meliss
Andreea Prisăcariu Ioana Loredana RoșcaSee main article: 2021 Amstelveen Women's Open – Singles.
See main article: 2021 Amstelveen Women's Open – Doubles.
Amina Anshba / 
Anastasia Dețiuc, 6–4, 6–3