| Date: | 14 – 20 June |
| Edition: | 6th |
| Draw: | 32S / 16D |
| Surface: | Clay |
| Location: | Almaty, Kazakhstan |
| Champs: | Jesper de Jong |
| Champd: |  Vladyslav Manafov / Vitaliy Sachko |
| Before Year: | 2021 |
| Before Name: | Almaty Challenger |
| Main Name: | Almaty Challenger |
| After Name: | Almaty Challenger |
The 2021 Almaty Challenger II was a professional tennis tournament played on clay courts. It was the sixth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Almaty, Kazakhstan between 14 and 20 June 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovakia | Andrej Martin | 108 | 1 | |
 Egypt | Mohamed Safwat | 162 | 2 | |
 Belgium | Kimmer Coppejans | 174 | 3 | |
 Italy | Lorenzo Giustino | 178 | 4 | |
 Kazakhstan | Dmitry Popko | 195 | 5 | |
 Uzbekistan | Denis Istomin | 204 | 6 | |
 Brazil | João Menezes | 211 | 7 | |
 Canada | Brayden Schnur | 225 | 8 |
The following players received entry into the singles main draw as wildcards:
Dostanbek Tashbulatov Denis Yevseyev Beibit ZhukayevThe following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Almaty Challenger II – Singles.
See main article: 2021 Almaty Challenger II – Doubles.
Vladyslav Manafov / Vitaliy Sachko def. 
Corentin Denolly / 
Adrián Menéndez Maceiras 6–1, 6–4.
