| Champ: |  Iga Świątek |
| Runner: | Belinda Bencic |
| Score: | 6–2, 6–2 |
| Draw: | 28 (6 / 4) |
| Seeds: | 8 |
| Edition: | 2nd |
| Type: | singles doubles |
| Before Name: | Adelaide International – Women's singles |
| After Name: | Adelaide International 1 – Women's singles |
See main article: 2021 Adelaide International. Ashleigh Barty was the defending champion,[1] but she lost in the second round to Danielle Collins, in a rematch of the previous year's semifinal.
Iga Świątek won the title, defeating Belinda Bencic in the final, 6–2, 6–2. Świątek did not drop a set throughout the entire tournament.
The top four seeds received a bye into the second round.