The 2021 Mexican Open (also known as the Abierto Mexicano Telcel presentado por HSBC for sponsorship reasons) was a professional tennis tournament played on outdoor hard courts. It was the 28th edition of the men's Mexican Open, and part of the 2021 ATP Tour.[1] It took place in Acapulco, Mexico between 15 and 20 March 2021, at the Princess Mundo Imperial.
See main article: article and 2021 Abierto Mexicano Telcel – Singles.
See main article: article and 2021 Abierto Mexicano Telcel – Doubles.
Ken Skupski / Neal Skupski def. 
Marcel Granollers / 
Horacio Zeballos, 7–6(7–3), 6–4| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
| Stefanos Tsitsipas | 4 | 1 | ||
| Alexander Zverev | 6 | 2 | ||
| Argentina | Diego Schwartzman | 9 | 3 | |
 Canada | Milos Raonic | 15 | 4 | |
| Grigor Dimitrov | 17 | 5 | ||
 Italy | Fabio Fognini | 18 | 6 | |
| Canada | Félix Auger-Aliassime | 19 | 7 | |
 Norway | Casper Ruud | 25 | 8 |
The following players received wildcards into the main draw:
The following player received entry using a protected ranking into the singles main draw:
The following player received special exemption into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Denis Kudla Pablo Andújar → replaced by Steve Johnson Salvatore Caruso Guido Pella → replaced by Cameron Norrie Sam Querrey → replaced by Feliciano López| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Spain | Marcel Granollers | Argentina | Horacio Zeballos | 18 | 1 | |
| United Kingdom | Jamie Murray |  Brazil | Bruno Soares | 25 | 2 | |
 France | Pierre-Hugues Herbert | France | Nicolas Mahut | 30 | 3 | |
| Rajeev Ram | United Kingdom | Joe Salisbury | 32 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry from the qualifying draw:
The following pair received entry as lucky losers:
