| Date: | 22–28 November 2021 |
| Edition: | 1st |
| Surface: | Clay / Outdoor (men) Clay / Indoor (women) |
| Location: | Brasília, Brazil |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Prize Money: | $52,080 (men) $60,000 (women) |
| Champms: |  Federico Coria |
| Champmd: |  Mateus Alves / Gustavo Heide |
| Champws: |  Panna Udvardy |
| Champwd: | Carolina Alves / María Lourdes Carlé |
The 2021 Aberto da República was a professional tennis tournament played on outdoor (men) and indoor (women) clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour and the 2021 ITF Women's World Tennis Tour. It took place in Brasília, Brazil between 22 and 28 November 2021.[1] [2]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Federico Coria | 69 | 1 | |
 Spain | Jaume Munar | 83 | 2 | |
| Argentina | ||||
| Argentina | Francisco Cerúndolo | 112 | 4 | |
 Bolivia, Plurination;al State of | Hugo Dellien | 120 | 5 | |
| Argentina | Tomás Martín Etcheverry | 129 | 6 | |
| Brazil | Thiago Seyboth Wild | 132 | 7 | |
| Argentina | Juan Ignacio Londero | 144 | 8 |
The following players received wildcards into the singles main draw:
Mateus Alves Gustavo Heide Wilson LeiteThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Hungary | Panna Udvardy | 115 | 1 | |
| Verónica Cepede Royg | 208 | 2 | ||
| Brazil | ||||
 Romania | Gabriela Lee | 229 | 4 | |
| Brazil | Carolina Alves | 258 | 5 | |
 Russian Federation | Elina Avanesyan | 261 | 6 | |
| Argentina | María Lourdes Carlé | 262 | 7 | |
 China | You Xiaodi | 265 | 8 |
The following players received wildcards into the singles main draw:
Ana Candiotto Sofia da Cruz Mendonça Júlia Klimovicz Maria Luisa OliveiraThe following players received entry using protected rankings:
Thaisa Grana Pedretti
Olivia TjandramuliaThe following players received entry from the qualifying draw:
Martina Capurro Taborda
Katarina Jokić
Sabastiani LeónThe following players received entry as lucky losers:
Maria Lota Kaul Noelia ZeballosSee main article: 2021 Aberto da República – Men's singles.
Federico Coria def. Jaume Munar 7–5, 6–3.See main article: 2021 Aberto da República – Women's singles.
Panna Udvardy def. Elina Avanesyan, 0–6, 6–4, 6–3See main article: 2021 Aberto da República – Men's doubles.
Mateus Alves / Gustavo Heide def. 
Luciano Darderi / Genaro Alberto Olivieri 6–3, 6–3.See main article: 2021 Aberto da República – Women's doubles.
Carolina Alves / María Lourdes Carlé def. 
Valeriya Strakhova / Olivia Tjandramulia 6–2, 6–1