| Competition: | AFA Senior Male League |
| Season: | 2021 |
| Continentalcup1: | Caribbean Club Shield |
| League Topscorer: |  Jonathan Guishard(10 goals) |
| Biggest Home Win: | WEP 1–12 DUFC |
| Biggest Away Win: | WEP 1–12 DUFC |
| Highest Scoring: | 13 goals WEP 1–12 DUFC |
| Longest Wins: | 8 games: Roaring Lions (12 Mar. - 25 Jul. 2021) |
| Longest Unbeaten: | 8 games: Roaring Lions (12 Mar. - 25 Jul. 2021) |
| Longest Winless: | 4 games: West End Predators (12 Mar. - 10 Apr. 2021) |
| Prevseason: | 2020 |
| Nextseason: | 2022 |
The 2021 AFA Senior Male League is the 21st season of the AFA Senior Male League, the men's football league in Anguilla. The season began on March 12, 2021.
Note: Table lists in alphabetical order.
| Team | Location | Stadium | Capacity | |
|---|---|---|---|---|
| ALHCS Spartan | The Valley | JRW Park | 200 | |
| Attackers | Stoney Ground | Little Dix Field | 100 | |
| Diamond | The Valley | JRW Park | 200 | |
| Doc's United | The Valley | JRW Park | 200 | |
| Enforcers | The Valley | Guishard Centre | 1,100 | |
| Kicks United | The Valley | Ronald Webster Park | 4,000 | |
| Lymers FC | The Valley | Guishard Centre | 1,100 | |
| Salsa Ballers | George Hill | Anguilla Community College | 100 | |
| Roaring Lions | The Valley | Ronald Webster Park | 4,000 | |
| Uprising | The Valley | Guishard Centre | 1,100 | |
| West End Predators | West End | Immanuel Methodist Church | 100 |
| Team | Pld | W | D | L | GF | GA | DG | Pts | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Roaring Lions FC (C) | 8 | 8 | 0 | 0 | 33 | 1 | 32 | 24 | |
| 2. | Kicks United FC | 9 | 7 | 0 | 2 | 27 | 8 | 19 | 21 | |
| 3. | Uprising FC | 8 | 5 | 1 | 2 | 16 | 12 | 8 | 16 | |
| 4. | Doc's United FC | 6 | 5 | 0 | 1 | 28 | 3 | 25 | 15 | |
| 5. | Lymers FC | 8 | 4 | 1 | 3 | 11 | 8 | 3 | 13 | |
| 6. | Attackers FC | 9 | 3 | 4 | 2 | 10 | 16 | -6 | 13 | |
| 7. | Diamond FC | 8 | 3 | 1 | 4 | 11 | 11 | 0 | 10 | |
| 8. | Enforcers FC | 8 | 2 | 1 | 5 | 15 | 16 | -1 | 7 | |
| 9. | Salsa Ballers FC | 9 | 2 | 0 | 7 | 11 | 32 | -21 | 6 | |
| 10. | 9 | 1 | 2 | 6 | 6 | 24 | -18 | 5 | ||
| 11. | 10 | 1 | 0 | 9 | 8 | 45 | -37 | 3 |