| Competition: | Divizia Națională |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Sheriff |
| Continentalcup2: | Conference League |
| Continentalcup2 Qualifiers: | Petrocub Milsami Sf. Gheorghe |
| Matches: | 112 |
| Total Goals: | 343 |
| League Topscorer: | Vladimir Ambros (17 goals) |
| Biggest Home Win: | |
| Biggest Away Win: | |
| Highest Scoring: | |
| Longest Wins: | 9 matches Sheriff |
| Longest Unbeaten: | 18 matches Sheriff |
| Longest Winless: | 28 matches Florești |
| Longest Losses: | 28 matches Florești |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Season: | 2021–22 |
| Winners: | Sheriff |
| Best Goalkeeper: | Georgios Athanasiadis (13 clean sheets) |
| Relegated: | Florești |
The 2021–22 Moldovan National Division (Romanian; Moldavian; Moldovan: Divizia Națională) was the 31st season of top-tier football in Moldova. The season started on 1 July 2021 and ended on 14 May 2022. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2022–23 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2022–23 UEFA Europa Conference League.[1]
A total of 8 teams are competing in the league. These include 7 teams from the 2020–21 season and one promoted team from the "A" Division: Bălți.
Bălți (promoted after a two-year absence) were promoted from the "A" Division. Dacia Buiucani (relegated after one year in the top flight) and Codru Lozova (relegated after two years in the top flight) were relegated to "A" Division. Additionally, Speranța Nisporeni were expelled from the league, and thus ending their six-year stay in the top flight.
| Team | Place | Ground | Capacity | Coach | |
|---|---|---|---|---|---|
| Bălți | Bălți | Bălți Stadium | 7,000 |  Serghei Cebotari | |
| Dinamo-Auto | Tiraspol | Dinamo-Auto Stadium | 1,300 | Oleg Bejenar | |
| Florești | Florești | Bender Stadium | 5,000 | Iurie Groșev | |
| Milsami | Orhei | CSR Orhei | 3,000 | Serghei Dubrovin | |
| Petrocub | Hîncești | Hîncești Stadium | 1,200 | ||
| Sfîntul Gheorghe | Suruceni | Zimbru-2 Stadium | 1,500 | Nicolai Mandrîcenco | |
| Sheriff | Tiraspol | Sheriff Stadium | 12,726 | Victor Mihailov | |
| Zimbru | Chișinău | Zimbru Stadium | 10,400 |  Michele Bon |
| Team | Outgoing manager | Manner of departure | Date of vacancy | Position in table | Replaced by | Date of appointment | |
|---|---|---|---|---|---|---|---|
| Sfîntul Gheorghe | Serghei Cebotari | Resigned | 27 September 2021 | 6th | Stanislav Luca | 28 September 2021[2] | |
| Zimbru | Vlad Goian | Demoted to assistant coach | 18 November 2021 | 7th | Michele Bon | 18 November 2021[3] | |
| Bălți |  Ihor Rakhayev | Resigned | 2 December 2021[4] | 6th | Serghei Cebotari | 10 January 2022[5] | |
| Sheriff | Yuriy Vernydub | Temporary leave to join Ukrainian Army | 28 February 2022[6] | 1st | Victor Mihailov (caretaker) | 1 March 2022 | |
| Dinamo-Auto |  Igor Dobrovolski | UEFA Pro Licence expired on 31.12.2021 | 13 March 2022 | 5th | Oleg Bejenar | 13 March 2022[7] | |
| Sfîntul Gheorghe | Stanislav Luca | No UEFA Pro Licence | 19 March 2022 | 4th | Nicolai Mandrîcenco | 19 March 2022[8] |
Teams played each other four times (twice at home, twice away).
The following table represents the teams game results in each round.[9]
| W #FFFFCC;" | D #FFCCCC;" | L --> | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bălți | W | L | D | W | L | W | W | L | D | L | L | L | W | W | L | L | L | L | L | L | W | L | W | D | W | L | W | W | |||
| Dinamo-Auto | L | D | W | L | L | L | L | D | W | W | W | L | L | L | W | L | W | W | L | D | W | D | L | W | L | L | L | D | |||
| Florești | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | L | |||
| Milsami Orhei | D | W | W | W | W | W | W | D | D | W | W | L | W | D | W | L | W | W | L | W | L | L | L | L | W | W | D | D | |||
| W | L | W | W | W | W | W | L | D | W | W | W | W | W | L | W | D | W | D | D | W | W | L | W | W | W | W | W | ||||
| Sfîntul Gheorghe | D | D | D | L | W | W | L | L | W | L | D | W | L | D | W | W | D | D | L | W | L | W | W | D | L | L | W | L | |||
| Sheriff Tiraspol | L | W | W | W | W | D | W | W | W | W | W | W | W | W | W | D | W | W | W | L | W | W | W | D | W | W | D | W | |||
| Zimbru Chișinău | W | W | L | L | L | L | D | W | D | L | D | L | L | L | W | L | L | D | L | W | L | D | W | D | L | W | L | L |
A play-off match was played between the seventh-placed team from Divizia Națională and the fourth-placed team from Divizia A for one place in the next season. The "home" team (for administrative purposes) was determined in a draw held on 19 May 2022.[10]
| Rank | Player | Club | Goals[11] |
|---|---|---|---|
| 1 | Vladimir Ambros | Petrocub | 17 |
| 2 | Sergiu Istrati | Milsami | 15 |
| 3 | Momo Yansané | Sheriff | 11 |
| Mihai Plătică | Petrocub | ||
| 5 |  Emmanuel Alaribe | Bălți | 8 |
 Adama Traoré | Sheriff | ||
| 7 | Victor Stînă | Sf. Gheorghe | 7 |
| Artem Fedorov | Petrocub (2) & Dinamo-Auto (5) | ||
| Serhii Molochko | Bălți | ||
| Nichita Moțpan | Bălți |
| Player | Home | Away | Result | Date | |
|---|---|---|---|---|---|
| | Milsami | 4–1 | |||
| | Milsami | 3–4 | |||
| | Petrocub | 3–0 | |||
| Sheriff | 4–0 | ||||
| | Petrocub | 5–0 |
| Rank | Player | Club | Clean sheets[12] |
|---|---|---|---|
| 1 | Georgios Athanasiadis | Sheriff | 13 |
| 2 | Emil Tîmbur | Milsami | 8 |
| 3 | Igor Mostovei | Petrocub | 6 |
| Mickaël Meira | Petrocub | ||
| Nicolai Calancea | Sf. Gheorghe | ||
| 6 | Victor Străistari | Bălți | 4 |
| Maxim Bardîș | Dinamo-Auto | ||
| 8 |  Razak Abalora | Sheriff | 3 |
| Silviu Șmalenea | Zimbru | ||
| 10 |  Dušan Marković | Sheriff | 2 |
| Cristian Apostolachi | Dinamo-Auto |