| Competition: | Iran Football's 2nd Division |
| Season: | 2021–22 |
| Winners: | Chooka Talesh |
| Promoted: | Chooka Talesh Shahin Bandar Ameri Van Pars Naghshe Jahan |
| Relegated: | Abi Poushan Tehran Iranjavan Bushehr Oghab Tehran Gol Reyhan Alborz |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season of Iran Football's 2nd Division was the 21st under 2nd Division since its establishment (current format) in 2001. The season featured 21 teams from the 2nd Division 2020–21, three new team relegated from the 2020–21 Azadegan League: Chooka Talesh, Navad Urmia, Gol Reyhan Alborz, and four new teams promoted from the 3rd Division 2020–21: Shahrdari Noshahr, Shahid Oraki Eslamshahr, Van Pars Naghsh-e-Jahan, Shohadaye Razakan Karaj.[1] The draw for the league was held on 26 October 2021.[2]
These changes has been applied before the season:
| Team | Replaced team | |
|---|---|---|
| Omid Genaveh | Payam Toos Khorasan | |
| Milad Mehr Iranian | Iman Sabz Shiraz | |
| Melli Haffari Ahvaz | Naft va Gaz Gachsaran | |
| Elmo Adab Tabriz | Besat Kermanshah | |
| Mohtasham Tabriz | Khalij Fars Mahshahr |
| Region | Number of teams | Teams | |
|---|---|---|---|
| 1 | Tehran | 5 | Abipooshan Omid Kousha, Espad Alvand, Shahid Oraki Eslamshahr, Oghab, Nirooye Zamini |
| 2 | Khuzestan | 3 | Foolad Novin, Shahrdari Mahshahr, Khalij Fars Mahshahr |
| 3 | Bushehr | 2 | Iranjavan, Shahin Bandar Ameri |
| 4 | Alborz | 2 | Gol Reyhan, Shohadaye Razakan |
| 5 | Gilan | 2 | Chooka Talesh, Sepidrood Rasht |
| 6 | Kerman | 2 | Mes Novin, Shahrdari Bam |
| 7 | Kermanshah | 2 | Besat |
| 8 | Mazandaran | 2 | Shahrdari Noshahr, Shohadaye Babolsar |
| 9 | Isfahan | 1 | Van Pars Naghsh-e-Jahan |
| 10 | Hamedan | 1 | Pas |
| 11 | Hormozgan | 1 | Shahrdari Bandar Abbas |
| 12 | Kohgiluyeh and Boyer-Ahmad | 1 | Naft va Gaz Gachsaran |
| 13 | North Khorasan | 1 | Atrak Bojnourd |
| 14 | Fars | 1 | Iman Sabz Shiraz |
| 15 | West Azerbaijan | 1 | Navad Urumia |
| 16 | Yazd | 1 | Shahid Ghandi Yazd |
| 17 | Razavi Khorasan | 1 | Payam Toos Khorasan |
Source=[3]
Van Pars Naghshe Jahan won 3-2 on aggregate and promoted to 2022-23 Azadegan league[4]