| Season: | 2021–22 |
| Dates: | 28 August 2021 – 22 May 2022 |
| Matches: | 240 |
| Total Goals: | 593 |
| League Topscorer Section: | Top scorers |
| League Topscorer: | Omer Atzili (20 goals) |
| Biggest Home Win: | Maccabi Haifa 6–0 F.C. Ashdod [1] |
| Biggest Away Win: | Bnei Sakhnin 0–6 Maccabi Haifa [2] |
| Highest Scoring: | Hapoel Nof HaGalil 2–6 Ironi Kiryat Shmona [3] |
| Longest Wins: | 10 — Maccabi Haifa[4] |
| Longest Winless: | 13 — Maccabi Petah Tikva[6] |
The 2021–22 Israeli Premier League, also known as Ligat Tel Aviv Stock Exchange[8] for sponsorship reasons, was the 23rd season since its introduction in 1999 and the 80th season of top-tier football in Israel.
A total of fourteen teams were competing in the league, including twelve sides from the 2020–21 season and two promoted teams from the 2020–21 Liga Leumit.
Hapoel Nof HaGalil and Hapoel Jerusalem were promoted from the 2020–21 Liga Leumit. Hapoel Nof HaGalil and Hapoel Jerusalem returned to the top flight after an absence of 15 and 21 years respectively.
Hapoel Kfar Saba and Bnei Yehuda were relegated to the 2021–22 Liga Leumit after finishing the 2020–21 Israeli Premier League in the bottom two places.
| Team | Outgoing manager | Manner of departure | Date of vacancy | Position in table | Incoming manager | Date of appointment |
|---|---|---|---|---|---|---|
| Ironi Kiryat Shmona |  Kobi Refua | End of contract | 30 May 2021 | Pre-season | [9] | 31 May 2021 |
| Beitar Jerusalem | | Caretaking spell over | 2 June 2021 | [10] | 2 June 2021 | |
| Maccabi Netanya | Sacked | 29 September 2021 | 14 | | 4 October 2021 | |
| Maccabi Tel Aviv | 26 October 2021 | 12 | (Temporary) | 26 October 2021 | ||
| Ironi Kiryat Shmona | | 8 November 2021 | 14 |  | 9 November 2021 | |
| Beitar Jerusalem | Left | 1 December 2021 | 11 | | 10 December 2021 | |
| Maccabi Tel Aviv | | Caretaking spell over | 9 December 2021 | 4 | | 9 December 2021 |
| Hapoel Tel Aviv | | Sacked | 19 December 2021 | 7 | Kobi Refua | 19 December 2021 |
| Maccabi Petah Tikva | | Left | 28 December 2021 | 14 | | 29 December 2021 |
| Hapoel Nof HaGalil | | Sacked | 5 January 2022 | 13 | Shay Barda | 5 January 2022 |
| Bnei Sakhnin | | 18 January 2022 | 6 | | 19 January 2022 | |
| Beitar Jerusalem | | Left | 26 January 2022 | 11 | (Temporary) | 26 January 2022 |
| Beitar Jerusalem | | Caretaking spell over | 3 February 2022 | | 3 February 2022 | |
| Hapoel Be'er Sheva | | Sacked | 1 March 2022 | 2 | | 1 March 2022 |
The number of foreign players were restricted to six per team, while only five could have been registered to a game.[11]
Key numbers for pairing determination (number marks position after 26 games)
The table lists the results of teams in each round.
Key numbers for pairing determination (number marks position after 26 games)
| Rank | Player | Club | Goals | ||||
|---|---|---|---|---|---|---|---|
| 1 | Omer Atzili | Maccabi Haifa | 20 | ||||
| 2 | Dean David | Maccabi Haifa | align=center rowspan=3 | 15 | |||
| Itamar Shviro | Ironi Kiryat Shmona | ||||||
| Stipe Perica | Maccabi Tel Aviv | ||||||
| 5 | Igor Zlatanović | Maccabi Netanya | align=center rowspan=1 | 12 | |||
| 6 | Alen Ožbolt | Hapoel Haifa | align=center rowspan=2 | 11 | |||
| Alon Turgeman | Hapoel Haifa | ||||||
| 8 |  Nikita Rukavytsya | Hapoel Be'er Sheva | align=center rowspan=2 | 10 | |||
| Ramzi Safouri | Hapoel Be'er Sheva | ||||||
| 10 | Guy Melamed | Bnei Sakhnin | align=center rowspan=4 | 9 | |||
| Dolev Haziza | Maccabi Haifa | ||||||
 Tjaronn Chery | Maccabi Haifa | ||||||
| Đorđe Jovanović | Maccabi Tel Aviv | ||||||
| 10 | Osher Davida | Hapoel Tel Aviv | align=center rowspan=5 | 8 | 11 | align=center rowspan=4 | 7 |
| Shoval Gozlan | Hapoel Hadera | ||||||
| Lameck Banda | Maccabi Petah Tikva | ||||||
 Godsway Donyoh | Maccabi Haifa | ||||||
| 11 | 6 players | 5--> | |||||
| Player | For | Against | Result | Date | Round |
|---|---|---|---|---|---|
| Alen Ožbolt | Hapoel Haifa | Beitar Jerusalem | 5–1 (H) | 29 January 2022 | 20 |
| Omer Atzili4 | Maccabi Haifa | F.C. Ashdod | 6–0 (H) | 7 February 2022 | 21 |
Martin Atemengue
