See main article: 2021–22 Indian Super League season.
| Indian Super League playoffs | |
| Year: | 2021–22 |
| Country: | India |
| Num Teams: | 4 |
| Champions: | Hyderabad |
| Runner-Up: | Kerala Blasters |
| Semi-Finalist1: | Jamshedpur |
| Semi-Finalist2: | ATK Mohun Bagan |
| Matches: | 5 |
| Goals: | 10 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Indian Super League playoffs was the eighth playoffs series of the Indian Super League, one of the top Indian professional football leagues. The playoffs began on 11 March 2022 and concluded with the final on 20 March in Goa.
The top four teams from the 2021–22 ISL regular season had qualified for the playoffs. The semi-finals took place over two legs while the final was a one-off match at the Fatorda Stadium in Margao, Goa.
Kerala Blasters won 2–1 on aggregate. ---- Hyderabad won 3–2 on aggregate.
See main article: 2022 Indian Super League Final.