| Competition: | Djibouti Premier League |
| Season: | 2021–22 |
| Winners: | Arta/Solar7 |
| Relegated: | EAD/PK 12 Arhiba FC |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Arta/Solar7 |
| Continentalcup2: | Confederation Cup |
| Continentalcup2 Qualifiers: | ASAS Djibouti Télécom |
| Date: | 22 October 2020 – 23 April 2022 |
| Matches: | 90 |
| Total Goals: | 276 |
| League Topscorer: | Gabriel Dadzie (18 goals) |
| Biggest Home Win: | Arta/Solar7 12–1 Arhiba (23 April 2022) |
| Biggest Away Win: | Arhiba 0–8 Port (11 February 2022) |
| Highest Scoring: | Arta/Solar7 12–1 Arhiba (23 April 2022) |
| Longest Wins: | ASAS Djibouti Télécom (6 matches) |
| Longest Unbeaten: | Arta/Solar7 (10 matches) |
| Longest Winless: | Arhiba (18 matches) |
| Longest Losses: | Arhiba (18 matches) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Djibouti Premier League was the 34th season of the Djibouti Premier League, the top-tier football league in Djibouti. The season began on 22 October 2021 and ended on 23 April 2022.[1] The 20,000-capacity El Hadj Hassan Gouled Aptidon Stadium is the main venue of the league.
Arta/Solar7, captained by former FC Barcelona midfielder Alex Song, won the league for the second consecutive season.[2] The team's forward, Gabriel Dadzie, won the Golden Boot award, scoring 18 goals.[3]
The two newly promoted teams, EAD/PK 12 and Arhiba FC, were both relegated. Arhiba lost every game while EAD / PK 12 finished 9th on goal difference after a 0–1 loss to FC Dikhil in their final match.