| Competition: | Cyta Championship |
| Season: | 2021–22 |
| Dates: | 20 August 2021 – May 2022 |
| Winners: | Apollon 4th title |
| Relegated: | Ethnikos Achna PAEEK |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Apollon AEK Larnaca |
| Continentalcup2: | Europa League |
| Continentalcup2 Qualifiers: | Omonia |
| Continentalcup3: | Europa Conference League |
| Continentalcup3 Qualifiers: | APOEL Aris Limassol |
| League Topscorer: | Giorgi Kvilitaia (11 goals) |
| Biggest Home Win: | Pafos 4–0 APOEL AEL Limassol 4–0 Pafos |
| Biggest Away Win: | PAEEK 2–5 AC Omonia |
| Highest Scoring: | PAEEK 2–5 AC Omonia |
| Matches: | 192 |
| Total Goals: | 456 |
| Longest Wins: | 5 matches AEK Larnaca Apollon Limassol |
| Longest Unbeaten: | 15 matches APOEL |
| Longest Winless: | 11 matches PAEEK |
| Longest Losses: | 5 matches Ethnikos Achna |
| Highest Attendance: | 13,233[1] APOEL 1–1 AEK |
| Attendance: | 390,458[2] |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 22 May 2022 |
The 2021–22 Cypriot First Division was the 83rd season of the Cypriot top-level football league.
Note: Table lists clubs in alphabetical order.
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players and Managers may hold more than one non-FIFA nationality.
| Team | Head coach | Captain | Kit manufacturer | Shirt sponsor | |
|---|---|---|---|---|---|
| AEK Larnaca |  David Badia |  Ivan Trichkovski | Puma | Bet on Alfa | |
| AEL Limassol | Savvas Pantelidis | André Teixeira | Macron | Parimatch | |
| Anorthosis Famagusta |  Temur Ketsbaia |  Kostakis Artymatas | Adidas | Allea Group | |
| APOEL | Sofronis Avgousti | Georgios Efrem | Macron | Stoiximan | |
| Apollon Limassol | Alexander Zorniger | Chambos Kyriakou | Puma | Stoiximan | |
| Aris Limassol |  Aleksey Shpilevsky | Gordon Schildenfeld | Jako | Parimatch | |
| Doxa Katokopias | Elias Charalambous |  Berat Sadik | Nike | Victory Ammunition | |
| Ethnikos Achna |  Andrej Razdrh | Martin Bogatinov | Jako | OPAP Cyprus | |
| Olympiakos Nicosia |  Nedim Tutic |  Kingsley Sarfo | Jako | Office Pro | |
| Omonia | Jordi Gómez | Macron | Stoiximan | ||
| PAEEK | Charalambos Aristotelous | Givova | |||
| Pafos FC | Jason Puncheon | Jako | Korantina Homes |
