| Mode: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Creighton Bluejays |
| Conference: | Big East |
| Short Conf: | Big East |
| Record: | 23–10 |
| Conf Record: | 15–5 |
| Hc Year: | 20th |
| Asst Coach1: | Linda Sayavongchanh |
| Asst Coach2: | Carli Berger |
| Asst Coach3: | Jordann Reese |
| Bowl Result: | Elite Eight |
The 2021–22 Creighton Bluejays women's basketball team represents Creighton University in the 2021–22 NCAA Division I women's basketball season. The Bluejays, led by 20th year head coach Jim Flanery, play their home games at D. J. Sokol Arena and are members of the Big East Conference.
[1] |-!colspan=9 style=|Exhibition|-!colspan=9 style=| Regular season|-!colspan=9 style=| Big East Tournament|-!colspan=9 style=| NCAA Tournament
See main article: 2021–22 NCAA Division I women's basketball rankings.