| Coppa Italia Serie C | |
| Year: | 2021–22 |
| Champions: | Padova |
| Runner-Up: | Südtirol |
| Matches: | 62 |
| Goals: | 154 |
| Top Goal Scorer: | Nicolás Bubas Mattia Minesso (4 goals each) |
| Country: | Italy |
| Dates: | 19 August 2021 – 6 April 2022 |
| Num Teams: | 60 |
| Prevseason: | 2019–20 |
| Nextseason: | 2022–23 |
| Defending Champions: | Juventus U23 |
The 2021–22 Coppa Italia Serie C was the 49th season of the Coppa Italia Serie C, the cup competition for Serie C clubs.
Juventus U23 were the defending champions having won their first title in June 2020 against Ternana, with a 2–1 final score in the final.[1]
The 2020–21 season was not held due to the COVID-19 pandemic.[2]
The 60 teams in the 2021–22 Serie C entered the competition at various stages, as follows:[3]
The schedule of each rounds were announced on 27 July 2021.[4]
| Phase | Round | First leg | Second leg |
|---|---|---|---|
| First stage | First round | 19 August & 21–22 August 2021 | |
| Second round | 8 September & 14–16 September 2021 | ||
| Final stage | Round of 16 | 3 November 2021 | |
| Quarter-finals | 24 November 2021 | ||
| Semi-finals | 15 December 2021 18 January 2022 | 19 January 2022 2 March 2022 | |
| Final | 9 March 2022 | 6 April 2022 | |
The draw was made on 9 August 2021.[5]
The round is contested by the winners of the previous round and the four teams that participated in the 2021–22 Coppa Italia.
Statistics include the goals scored by Pro Patria and Lucchese against FeralpiSalò and Legnago, for a total of 154 goals.
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 |  Nicolás Bubas | Fidelis Andria | 4 | |
 Mattia Minesso | Modena | |||
| 3 | Alfredo Bifulco | Padova | 3 | |
| Daniel Birligea | Teramo | |||
| Leonardo Candellone | Südtirol | |||
| Raphael Odogwu | ||||
| 7 | Iacopo Cernigoi | Seregno | 2 | |
| Matteo Di Piazza | Fidelis Andria | |||
| Giuseppe Fella | Palermo | |||
| Manuel Fischnaller | Südtirol | |||
| Vincenzo Garofalo | Foggia | |||
| Pasquale Maiorino | Virtus Francavilla | |||
| Filippo Moscati | Grosseto | |||
| Tino Parisi | Piacenza | |||
| Matías Soulé | Juventus U23 | |||
| Giacomo Tomaselli | AlbinoLeffe | |||
| 17 | 109 players | 1 | ||
| Player | Club | Opponents | |
|---|---|---|---|
| Nicholas Fantoni | ACR Messina | Juve Stabia | |
| Fabio Longo | Turris | Viterbese | |
| Antonio Narciso | Modena | Piacenza | |
| Leonardo Nunzella | Fidelis Andria | Südtirol | |
| Arensi Rota | Carrarese | Imolese |