| Mode: | Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Colorado Buffaloes |
| Conference: | Pac-12 Conference |
| Conference Link: | Pac-12 Conference men's basketball |
| Short Conf: | Pac-12 |
| Record: | 21–12 |
| Conf Record: | 12–8 |
| Hc Year: | 12th |
| Asst Coach1: | Mike Rhon |
| Tourney Result: | First Round |
The 2021–22 Colorado Buffaloes men's basketball team represented the University of Colorado Boulder in the 2021–22 NCAA Division I men's basketball season. They were led by head coach Tad Boyle in his twelfth season at Colorado. The Buffaloes played their home games at CU Events Center in Boulder, Colorado as members of the Pac-12 Conference. They finished the season 21–12, 12–8 in Pac-12 Play to finish in 4th place. They defeated Oregon in the quarterfinals of the Pac-12 tournament before losing in the semifinals to Arizona. They received an at-large bid to the National Invitation Tournament where they lost in the first round to St. Bonaventure.
In a season limited due to the ongoing COVID-19 pandemic, the Buffaloes finished the 2019–20 season 23–9, 14–6 in Pac-12 play to finish in third place. They advanced to the championship game of the Pac-12 tournament where they lost to Oregon State. They received an at-large bid to the NCAA basketball tournament as the No. 5 seed in the East Region where defeated Georgetown in the first round before losing to Florida State in the second round.
| Name | Num | Pos. ! | Height | Weight | Year | Hometown | Reason for departure | |
|---|---|---|---|---|---|---|---|---|
| Maddox Daniels | 3 | G/F | 6'6" | 211 | Senior | Graduated | ||
| D'Shawn Schwartz | 5 | G/F | 6'7" | 232 | Senior | Graduate transferred to George Mason | ||
| Alexander Strating | 10 | F | 6'7" | 228 | RS Senior | Graduate transferred to Missouri S&T | ||
| Dallas Walton | 13 | F/C | 7'0" | 235 | RS Senior | Graduate transferred to Wake Forest | ||
| Owen Koonce | 15 | G | 6'5" | 180 | Freshman | Walk-on; transferred to Colorado Mesa | ||
| 25 | G | 6'0" | 196 | Senior | Graduated; undrafted in 2021 NBA draft | |||
| Aidan McQuade | 33 | G | 6'2" | 195 | Senior | Walk-on; graduated | ||
| Isaac Jessup | 40 | G | 6'2" | 175 | Freshman | Walk-on; transferred to Colorado Mesa | ||
| Jeriah Horne | 41 | F | 6'7" | 220 | RS Senior | Graduate transferred to Tulsa |
[1] |-!colspan=12 style=| Costa Rican exhibition trip|-!colspan=12 style=| Exhibition|-!colspan=12 style=| Regular season |-!colspan=12 style=| Pac-12 tournament|-!colspan=12 style=| NIT tournament
See also: 2021–22 NCAA Division I men's basketball rankings. *AP does not release post-NCAA Tournament rankings.