| Tourney Name: | CAF Champions League |
| Year: | 2021–22 |
| Other Titles: | 2021–22 TotalEnergies CAF Champions League |
| Size: | 275 |
| Num Teams: | Main Competition: 16 Total: 54 |
| Associations: | 42 |
| Champion Other: | Wydad AC |
| Count: | 3 |
| Second Other: | Al Ahly |
| Matches: | 61 |
| Goals: | 134 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 CAF Champions League (known as the 2021–22 TotalEnergies CAF Champions League[1] for sponsorship purposes) was the 58th season of Africa's premier club football tournament organized by the Confederation of African Football (CAF), and the 26th season under the current CAF Champions League title.
Wydad Casablanca won their 3rd title with a 2–0 win against the defending champions, Al Ahly, in the final at Stade Mohammed V in Casablanca, Morocco, which hosted a second consecutive final. As winners, Wydad earned the right to play against RS Berkane, the winners of the 2021–22 CAF Confederation Cup, in the 2022 CAF Super Cup.[2]
A total of 42 out of the 56 CAF member associations entered this season's CAF Champions League, with the 12 highest ranked associations according to their CAF 5-year ranking eligible to enter two teams in the competition.[2] For this season, the CAF utilized the 2017–2021 CAF 5-year ranking, which calculated points for each entrant association based on their clubs’ performance over those 5 years in the CAF club competitions. The criteria for points were as follows:[3] [4] [5]
| CAF Champions League | CAF Confederation Cup | ||
|---|---|---|---|
| Winners | 6 points | 5 points | |
| Runners-up | 5 points | 4 points | |
| Losing semi-finalists | 4 points | 3 points | |
| Losing quarter-finalists | 3 points | 2 points | |
| 3rd place in groups | 2 points | 1 point | |
| 4th place in groups | 1 point | 0.5 point |
The points were multiplied by a coefficient according to the year as follows:
The following 54 teams from 42 out of the total 54 member associations entered this season's tournament.
Associations are shown according to their 2017–2021 CAF 5-year ranking – those with a ranking score have their rank and score (in parentheses) indicated.
Notes:
The schedule for this season's edtition of the tournament were as follows:
| Phase | Round | Draw date | First leg | Second leg |
|---|---|---|---|---|
| Qualification | First round | 13 August 2021 | 10–12 September 2021 | 17–19 September 2021 |
| Second round | 15–17 October 2021 | 22–24 October 2021 | ||
| Group stage | Matchday 1 | 28 December 2021 | 11–12 February 2022 | |
| Matchday 2 | 18–19 February 2022 | |||
| Matchday 3 | 25–26 February 2022 | |||
| Matchday 4 | 11–12 March 2022 | |||
| Matchday 5 | 18–19 March 2022 | |||
| Matchday 6 | 1–2 April 2022 | |||
| Knockout stage | Quarter-finals | 5 April 2022 | 15–16 April 2022 | 22–23 April 2022 |
| Semi-finals | 6–7 May 2022 | 13–14 May 2022 | ||
| Final | 30 May 2022 at Stade Mohammed V, Casablanca | |||
See main article: 2021–22 CAF Champions League qualifying rounds.
See main article: 2021–22 CAF Champions League group stage. In the group stage, each group was played on a home-and-away round-robin basis. The winners and runners-up of each group advanced to the quarter-finals of the knockout stage.
See main article: 2021–22 CAF Champions League knockout stage.
See main article: 2022 CAF Champions League Final.
| Rank | Player | Team |    | Total | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Tiago Azulão | Petro de Luanda | 1 | 1 | 2 | 1 | 1 | bgcolor=silver colspan=1 | 6 | ||||||
| 2 |  Mohamed Sherif | Al Ahly | 2 | 1 | 1 | 1 | 5 | ||||||||
 Zouhair El Moutaraji | Wydad AC | 1 | 1 | 1 | 2 | ||||||||||
| 4 |  Mohamed Ali Ben Romdhane | Espérance de Tunis | 3 | 1 | 4 | ||||||||||
| Yahya Jabrane | Wydad AC | 1 | 1 | 1 | 1 | ||||||||||
| Riad Benayad | ES Sétif | 1 | 2 | 1 | bgcolor=silver colspan=1 | ||||||||||
| 7 |  Elsamani Saadeldin | Al Merrikh | 1 | 2 | bgcolor=silver colspan=5 | 3 | |||||||||
| Kheireddine Merzougui | CR Belouizdad | 2 | 1 | bgcolor=silver colspan=3 | |||||||||||
| Thapelo Morena | Mamelodi Sundowns | 1 | 2 | bgcolor=silver colspan=3 | |||||||||||
 Kingsley Eduwo | Espérance de Tunis | 1 | 2 | bgcolor=silver colspan=3 | |||||||||||
| Gilbert Baruti | Jwaneng Galaxy | 1 | 2 | bgcolor=silver colspan=5 | |||||||||||
| Guy Mbenza | Wydad AC | 1 | 1 | 1 | |||||||||||
| Percy Tau | Al Ahly | 1 | 2 | ||||||||||||