| Club: | ZZ Leiden |
| Season: | 2021–22 |
| Manager: | Geert Hammink (2nd season) |
| Stadium: | Vijf Meihal |
| League: | BNXT League |
| League Result: | Champions |
| League2: | Basketball Cup |
| League2 Result: | Semifinalist |
| Cup1: | BNXT Supercup |
| Cup1 Result: | Runner-up (lost to Oostende) |
| Cup2: | Dutch Supercup |
| Cup2 Result: | Winners (defeated BAL) |
| Cup3: | FIBA Europe Cup |
| Cup3 Result: | Semifinalists |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 ZZ Leiden season was the 35th season in the existence of the club, and the 15th season under the entity of ZZ Leiden. The club played its first season in the BNXT League, the newly established league which combines the Belgian and Dutch national leagues.
Leiden won the inaugural BNXT championship and finished as runners-up in the Dutch playoffs.
| Competition | Round | Pld | W | L | Result | |
|---|---|---|---|---|---|---|
| BNXT League | National Round | 20 | 17 | 3 | 2nd place | |
| Elite Gold | 10 | 6 | 4 | 3rd place | ||
| National playoffs | 5 | 6 | 2 | Runners-up | ||
| BNXT playoffs | 4 | 3 | 1 | Champion | ||
| 5 | 4 | 1 | Semifinalist | |||
| Dutch Supercup | 1 | 1 | 0 | Champion | ||
| BNXT Supercup | 1 | 0 | 1 | Runner-up | ||
| Europe | ||||||
| Basketball Champions League | Qualifying rounds | 2 | 1 | 1 | Semifinals | |
| FIBA Europe Cup | Regular season | 6 | 3 | 3 | Semifinalist | |
| Second round | 6 | 4 | 2 | |||
| Playoffs | 4 | 1 | 3 | |||
| Total | 64 | 46 | 18 | |||
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|-!colspan=12 style=""|Regular season|-!colspan=12 style=""|Second round|-|-!colspan=12 style=""|Quarterfinals|-|-!colspan=12 style=""|Semifinals|-|}