| Sport: | Women's Basketball |
| Year: | 2021–22 |
| Team: | Villanova Wildcats |
| Conference: | Big East Conference |
| Short Conf: | Big East |
| Record: | 24–9 |
| Conf Record: | 15–4 |
| Hc Year: | 2nd |
| Asst Coach1: | Joe Mullaney |
| Asst Coach2: | Michelle Sword |
| Asst Coach3: | Mary Wooley |
| Tourney Result: | second round |
The 2021–22 Villanova Wildcats women's basketball team represented Villanova University in the 2021–22 NCAA Division I women's basketball season. The Wildcats, led by 2nd-year head coach Denise Dillon, played their home games at the Finneran Pavilion and were members of the Big East Conference.
[1] |-!colspan=9 style=| Exhibition|-!colspan=9 style=| Regular season|-!colspan=9 style=| Big East Women's Tournament|-!colspan=9 style=| NCAA Women's Tournament
See also: 2021–22 NCAA Division I women's basketball rankings.
| + Regular Season Polls | Poll | Pre- Season | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | Week 16 | Week 17 | Week 18 | Week 19 | Final |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP | RV | RV | RV | RV | RV | ||||||||||||||||
| Coaches |
| Increase in ranking | |||
| Decrease in ranking | |||
| Not ranked previous week | |||
| (RV) | Received Votes |