| Club: | Venezia |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Duncan L. Niederauer |
| Mgrtitle: | Manager |
| Manager: | Paolo Zanetti (until 27 April) Andrea Soncin (caretaker, from 27 April) |
| Stadium: | Stadio Pier Luigi Penzo |
| League: | Serie A |
| League Result: | 20th (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Thomas Henry (9) |
| Season Topscorer: | Thomas Henry (9) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 115th season in the existence of Venezia F.C. and the club's first season back in the top flight of Italian football since 2001–02. In addition to the domestic league, Venezia participated in this season's edition of the Coppa Italia.
Include players not registered for current season.
| scope=col | Player | Transferred from | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 28 | LASK | Undisclosed | [1] | |||||||
| 42 | Maccabi Tel Aviv | Undisclosed | [2] [3] | |||||||
| 22 | Benfica | Loan | [4] | |||||||
| 8 | FC Dallas | Undisclosed | [5] [6] | |||||||
| 11 | CSKA Moscow | Loan | [7] [8] | |||||||
| 27 | Sporting Kansas City | Undisclosed | [9] [10] | |||||||
| 31 | Milan | Loan | [11] | |||||||
| 77 | Club Brugge | Loan | [12] | |||||||
| 14 | OH Leuven | Undisclosed | [13] | |||||||
| 55 | Feyenoord | Undisclosed | [14] | |||||||
| 44 | Chelsea | Loan | [15] | |||||||
| Philadelphia Union | Loan | [16] | ||||||||
| 88 | Unattached | [17] | ||||||||
| 21 | Bayern Munich | €4,500,000 | [18] | |||||||
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[19]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style=background:#DCDCDC; text-align:center| Goalkeepers
|-! colspan=14 style=background:#DCDCDC; text-align:center| Defenders|-! colspan=14 style=background:#DCDCDC; text-align:center| Midfielders
|-! colspan=14 style=background:#DCDCDC; text-align:center| Forwards
|-! colspan=14 style=background:#DCDCDC; text-align:center| Player transferred out during the season|-