| Mode: | Women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Vanderbilt Commodores |
| Conference: | Southeastern Conference |
| Short Conf: | SEC |
| Record: | 16–19 |
| Conf Record: | 4–12 |
| Hc Year: | 1st |
| Asst Coach2: | Ashley Earley |
| Asst Coach3: | Kevin DeMille |
| Bowl Result: | Third Round |
The 2021–22 Vanderbilt Commodores women's basketball team represented Vanderbilt University during the 2021–22 NCAA Division I women's basketball season. The Commodores, led by first-year head coach Shea Ralph, played their home games at Memorial Gymnasium and competed as members of the Southeastern Conference (SEC).
The Commodores finished the season 4–4 (0–3 SEC) after cutting their season short due to COVID-19. Head coach Stephanie White was fired after five seasons. UConn assistant Shea Ralph was hired to replace her.
| Name | Number | Pos. | Height | Year | Hometown | Notes | |
|---|---|---|---|---|---|---|---|
| Enna Pehadzic | 1 | G | 5'9" | RS Senior | Horsens, Denmark | Graduated | |
| Chelsie Hall | 2 | G | 5'7" | Senior | Boca Raton, FL | Transferred to Louisville | |
| Koi Love | 23 | F | 6'0" | Sophomore | Orlando, FL | Transferred to Arizona | |
| Autumn Newby | 24 | F | 6'2" | Senior | Lawrenceville, GA | Transferred to LSU | |
| Kyndall Golden | 25 | F | 6'3" | Sophomore | Atlanta, GA | Left team | |
| Emily Bowman | 44 | C | 6'6" | Freshman | Huntsville, AL | Transferred to Samford | |
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|-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| SEC regular season|-!colspan=9 style=| SEC Tournament|-!colspan=9 style=| WNIT