| Competition: | Uganda Premier League |
| Season: | 2021–22 |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Vipers SC |
| Continentalcup2: | Confederation Cup |
| Continentalcup2 Qualifiers: | Bul FC |
| Matches: | 240 |
| Total Goals: | 587 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Uganda Premier League was the 54th season of the Uganda Premier League, the top-tier football league in Uganda.
Vipers SC won the championship with four games to go, finishing 18 points above second-placed KCCA.[1] Tooro United were also confirmed relegated with four games to go.[2]
Onduparaka FC were docked two points and two goals and were made to replay their December match against KCCA after violence broke out when a penalty was awarded in the 5th minute of extra time.[3]
Three teams were promoted from the 2020–21 FUFA Big League, which ended early due to a 42-day lockdown as a result of the COVID-19 pandemic. Arua Hill and Tooro United had already clinched promotion at that point and were promoted.[4] Gaddafi FC were the third team promoted after defeating Proline 2–0 in the final of a four-team playoff held in August 2021.[5]
They replaced Kyetume FC, MYDA, and Kitara, who were relegated from the 2020–21 season.