| Club: | Udinese |
| Season: | 2021–22 |
| Ownertitle: | Owner |
| Owner: | Giampaolo Pozzo |
| Chrtitle: | President |
| Chairman: | Franco Soldati |
| Mgrtitle: | Manager |
| Manager: | Luca Gotti (until 7 December) Gabriele Cioffi (caretaker, from 7 December) |
| Stadium: | Stadio Friuli |
| League: | Serie A |
| League Result: | 12th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Gerard Deulofeu (13) |
| Season Topscorer: | Gerard Deulofeu (13) |
| Pattern B1: | _udinese2122h |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 125th season in the existence of Udinese Calcio and the club's 27th consecutive season in the top flight of Italian football. In addition to the domestic league, Udinese participated in this season's edition of the Coppa Italia.
Features player not included in main roster.
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[2]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center"| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center"| Defenders|- ! colspan=14 style=background:#dcdcdc; text-align:center"| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center"| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center"| Players transferred out during the season