| Club: | US Biskra |
| Season: | 2021–22 |
| Manager: | Youcef Bouzidi [1] |
| Mgrtitle: | Head coach |
| Chairman: | Abdelkader Triaa |
| Chrtitle: | President |
| Stadium: | 18 February Stadium |
| League: | Ligue 1 |
| League Result: | 10th |
| League Topscorer: | Hichem Mokhtar (12 goals) |
| Season Topscorer: | Hichem Mokhtar (12 goals) |
| Largest Win: | 5–0 vs RC Arbaâ (A) (23 October 2021) |
| Largest Loss: | 0–3 vs USM Alger (A) (20 November 2021) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
In the 2021–22 season, US Biskra competed in the Ligue 1 for the fifth season, as well as the Algerian Cup. It was their third consecutive season in the top flight of Algerian football.
Players and squad numbers last updated on 20 October 2021.[2]
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
| No. | Nat. | Position | Name | Date of birth (age) | Signed from |
|---|---|---|---|---|---|
| Goalkeepers | |||||
| 1 | GK | Abderrahmane Bouchareb | January 1, 2022 | Youth system | |
| 13 | GK | Walid Ouabdi | January 1, 2022 | SC Aïn Defla | |
| 16 | GK | Ali Bencherif | January 1, 2022 | MO Béjaïa | |
| Defenders | |||||
| 3 | RB | Mohamed Assil Sioued | January 1, 2022 | Youth system | |
| 4 | CB | Tarek Adouane | January 1, 2022 | CRB Ouled Djellal | |
| 14 | CB | Mohamed Ikbal Boufligha | January 1, 2022 | CR Village Moussa | |
| 17 | RB | Bilal Boukarroum | January 1, 2022 | JSM Skikda | |
| 20 | CB | Nacereddine Khoualed | January 1, 2022 | JS Saoura | |
| 23 | CB | Adel Lakhdari | January 1, 2022 | MC Oran | |
| 26 | CB | Hamza Salem | January 1, 2022 | Youth system | |
| Midfielders | |||||
| 5 | MF | Ali Amriche | January 1, 2022 | CA Bordj Bou Arreridj | |
| 6 | MF | Hamza Heriat | January 1, 2022 | MC Oran | |
| 8 | MF | Mustapha Zeghnoun | January 1, 2022 | ASO Chlef | |
| 11 | MF | Hamza Ounnas | January 1, 2022 | USM Bel Abbès | |
| 18 | MF | Mohamed Fenniri | January 1, 2022 | Paradou AC | |
| 22 | MF | Hatem Dakhia | January 1, 2022 | ASO Chlef | |
| 24 | MF | Noufel Ghassiri | January 1, 2022 | Unattached | |
| 25 | MF | Mohamed Chaibeddra Tani | January 1, 2022 | Unattached | |
| 27 | MF | Hamza Yadroudj | January 1, 2022 | JS Saoura | |
| Forwards | |||||
| 7 | FW | Youcef Djahnit | January 1, 2022 | CS Constantine | |
| 9 | FW | Mohamed Larbi Khoualed | January 1, 2022 | CRB Ouled Djellal | |
| 10 | FW | Hichem Mokhtar | January 1, 2022 | JSM Béjaïa | |
| 12 | FW | El Hocine Rais | January 1, 2022 | GC Mascara | |
| 15 | FW | Aimen Djebbar | January 1, 2022 | Youth system | |
| 21 | FW | Hamza Demane | January 1, 2022 | AS Ain M'lila | |