| Club: | Salernitana |
| Season: | 2021–22 |
| Chrtitle: | CEO |
| Chairman: | Danilo Iervolino |
| Mgrtitle: | Manager |
| Manager: | Fabrizio Castori (until 17 October) Stefano Colantuono (from 17 October to 15 February) Davide Nicola (from 15 February) |
| Stadium: | Stadio Arechi |
| League: | Serie A |
| League Result: | 17th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Second round |
| League Topscorer: | Federico Bonazzoli (10) |
| Season Topscorer: | Federico Bonazzoli (12) |
| Pattern B1: | _salernitana2122h |
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| Pattern B2: | _salernitana2122a |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 103rd season in the existence of U.S. Salernitana 1919 and the club's first season back in the top flight of Italian football since 1999. In addition to the domestic league, Salernitana participated in this season's edition of the Coppa Italia.
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[1]
See main article: 2021–22 Coppa Italia.